Retsevmo / Selpercatinib 40mgг 120 tab, generic

Indication

Selpercatinib is approved to treat:

adult with locally advanced or metastatic non-small cell lung cancer (NSCLC) with a rearranged during transfection (RET) gene fusion.9 In Europe, patients should require systemic therapy following prior treatment with immunotherapy and/or platinum-based chemotherapy.8

adults and children 2 years of age and older with advanced or metastatic medullary thyroid cancer (MTC) with a RET mutation who require systemic therapy.9 In Europe, patients should be ≥12 years of age and previously treated with sorafenib, lenvatinib, cabozantinib and/or vandetanib.8

adults and children 2 years of age and older with advanced or metastatic thyroid cancer with a RET gene fusion who require systemic therapy and who are radioactive iodine-refractory (if radioactive iodine is appropriate) 9

adults and children 2 years of age and older with locally advanced or metastatic solid tumors with a RET gene fusion that have progressed on or following prior systemic treatment or who have no satisfactory alternative treatment options 9

Selpercatinib is currently approved for these indications under an accelerated approval scheme and continued approval may be contingent on future confirmatory trials.7